Unlike many other Dungeons & Dragons web shows, Dropout's Dimension 20 has a more anthology format to its storytelling. Each season tells its own narrative, largely disconnected from the others. There are some sequels with overarching storylines, but the show mostly follows self-contained campaigns, each in its own setting.
Source:https://www.cbr.com/dimension-20-dungeons-and-dragons-campaign-locations-ranked/