Star Wars Episode II: Attack of the Clones includes a Separatist plot to kill Senator Padmé Amidala (Natalie Portman), forcing the Republic and the Jedi to protect her from her would-be assassins. Much of the film's plot revolves around Anakin Skywalker (Hayden Christensen) becoming Padmé's bodyguard, taking her to Naboo, Tatooine, and Geonosis as he tries to keep her from falling into Separatist clutches. Nevertheless, the film never answers why Chancellor Sheev Palpatine (Ian McDiarmid), the true power behind the Separatists, wanted Amidala dead in the first place.
Source:https://www.cbr.com/star-wars-padme-palpatine-dead/