Most major Marvel villains have a nemesis with which they constantly do battle with. They are still significant threats, and occasionally it takes more than one hero to beat them. But ultimately those antagonists hold a specific grudge against a single vigilante or team. On the flip side, there are some villains that have come to form that aggressive bond with an array of characters who they would deem to be arch-nemeses.
Source：https://www.cbr.com/marvel-comics-villains-vs-many-arch-enemies/
