Spider-Man fights some truly dangerous villains. Oftentimes, it's intelligence that's the biggest threat. Norman Osborn's long-term calculations have put Spider-Man through the wringer, and Kraven's craftiness has trapped him. Doctor Octopus possesses a scientific mind as well as a secretive and underhanded one. He may be Spider-Man's worst villain.
Source：https://www.cbr.com/dangerous-doc-ock-secrets/
