All season long, What We Do in the Shadows teased a major conflict between Nandor and Guillermo. Sure, there have been kooky arcs such as Nadja bullying the Guide, and Colin Robinson being the most interesting person on Staten Island. But it did feel like it was all coming to a boil, given Guillermo was turned into a vampire.
Source:https://www.cbr.com/what-we-do-in-the-shadows-season5-ending-explained/