House Targaryen is the most popular house on Game of Thrones. Even people who've never seen the series or its spinoff, House of the Dragon, know that it's full of dragons and blonde-haired people. This is all thanks to Daenerys Targaryen's popularity. The claim to the Iron Throne is central to the two core Targaryen plots of Game of Thrones and House of the Dragon.
Source:https://www.cbr.com/house-targaryen-game-of-thrones-books-differences/