After the ending of Spider-Man: No Way Home, the world no longer remembers Peter Parker. As a result, he had to restart his life without the help of his family or friends, who would usually be by his side. There have been rumors that both Tom Holland and Zendaya will be reprising their roles as Peter Parker and MJ for Spider-Man 4. However, Zendaya may take a more minor role in Spider-Man 4 as MJ no longer remembers Peter.
Source：https://www.cbr.com/tom-holland-peter-parker-no-love-interest-spider-man-4/
