A major problem in Prime Video's Invincible revolves around the idea of who can kill Omni-Man. The comics painted him as more or less invulnerable, which the show has also abided by. Let's be real; as strong as Mark Grayson is, he's nowhere near Nolan's league.
Source:https://www.cbr.com/invincible-atom-eve-omni-man-killer/