With no Targaryen blood in her veins, Alicent Hightower managed to be one of the most manipulative (and manipulated) players in the Targaryen civil war known as the Dance of the Dragons. Her marriage to King Viserys I led to four Targaryen children, the oldest of whom plots to steal the throne from the rightful heir and older sister Rhaenyra Targaryen.
Source:https://www.cbr.com/who-is-alicent-hightower-house-of-the-dragon/