Author Hiromu Arakawa's hit shonen manga series Fullmetal Alchemist inspired a 2009 anime of the same name, both telling the same incredible story of redemption, hope, and the power of the human spirit. The story of Fullmetal Alchemist: Brotherhood also features a memorable combat system based on alchemy, but not the "turn lead into gold" sort found in real-life historical lore. In Fullmetal Alchemist: Brotherhood, alchemy is the art of understanding, deconstructing, and reshaping matter, which calls for tools like transmutation circles.
Source:https://www.cbr.com/fullmetal-alchemist-transmutation-circle-facts/