The X-Men have plenty of enemies and have suffered all sorts of dark periods, but the Fall of X storyline has taken things to another level entirely. With the world increasingly turning against the X-Men and their allies at large, it increasingly looks like the Marvel Universe is approaching a grim direction. It doesn't help that one of Spider-Man's oldest enemies is hard at work making that nightmare a reality, and it could make him a far more specific enemy to the mutant heroes going forward.
Source:https://www.cbr.com/xmen-spiderman-vulture-orchis-marvel-comics/