Throughout the story of One Piece, protagonist Monkey D. Luffy made various powerful enemies, including among his fellow pirates and certainly the World Government and its Navy armada. That includes various admirals, vice admirals, and even head admirals, though Luffy usually escaped their wrath without too much trouble. Luffy survived admiral Akainu's attack at the Marineford battle, for example, but Luffy and the Marines might soon cross paths again as the long-awaited war unfolds.
Source:https://www.cbr.com/one-piece-admiral-kizaru-final-fight/