During Nick Spencer's Spider-Man run, the wall-crawler's battle with Kindred revealed that, contrary to popular belief, it is Mephisto who deserves the title of Spider-Man's nemesis. The demonic entity was not only responsible for some of the most traumatizing moments in Peter Parker's life, but is also Spider-Man's perfect opposite. And if his words and visions about Spider-Man are to be believed, then the two are on a collision course to battle for the fate of the world.
Source：https://www.cbr.com/spider-man-real-nemesis-mephisto/
