The Big Bang Theory found memorable ways to set itself apart from other sitcoms like Seinfeld, Friends, and How I Met Your Mother. Unlike those other sitcoms, The Big Bang Theory focused on pop culture and the world of science, mainly through its main quartet of smart scientist friends. Sheldon, Leonard, Raj and Howard were all about high-tech science experiments and comic book store visits. However, their story didn't completely transform how sitcoms work.
Source：https://www.cbr.com/the-big-bang-theory-best-sitcom-tropes/
