Darth Vader is among the most iconic villains in all cinema. Known for his menacing armor, his sinister demeanor and his penchant for Force-choking colleagues without warning, he's quite the fearsome Sith Lord. It's difficult to imagine Vader being afraid of anyone. However, in a now non-canon comic, Star Wars: Vector, published by Dark Horse Comics in 2008, Vader faced a spirit so terrifying that he actually ran for his life.
Source:https://www.cbr.com/darth-vader-fled-jedi-sith-celeste-morne-star-wars/