Peter Parker and Miles Morales are currently the two most iconic iterations of Spider-Man in Earth-616. But the multiverse is vast and multiple other characters have stepped into the web-head's role, taking over for Peter and Miles and leaving their own legacy in a different reality. Marvel loves seeing what would happen if Spidey's friends and enemies begin to don the mask.
Source：https://www.cbr.com/spiderman-best-candidates-alternate-universes-marvel-comics/
