When it comes to Spider-Man villains, most of his baddies are thieves and neer-do-wells, though a few of them also gained incredible superpowers. Since some of these foes, like Mysterio or Electro, would lose in a fistfight to an average guy at a bar, some fans are left wondering "Who is Spider-Man's strongest enemy?"
Source:https://www.cbr.com/spider-man-strongest-villains/