Marvel's Jessica Jones boasted some of the most fascinating villains in the franchise. They ran the gamut from the truly terrifying, manipulative Kilgrave to Jessica's own mother, Alisa, who was far more sympathetic but still frightening in her own way. However, though Alisa was the primary antagonist of the show's second season, she is far from the worst character. No, that award goes to Trish Walker, Jessica's adoptive sister and best friend.
Source:https://www.cbr.com/jessica-jones-mcu-season2-villain-trish-walker/