Spider-Man has one of the most famous roster of rogues in the Marvel Universe. But times are changing and some of the villains that were once prominent threats are either allies of the web-slinger or just don't work quite like they used to. Years of continuity have depowered a couple of antagonists while redeeming others. New foes have risen to take their place and freshen up Spidey's stories, and perhaps one day those notable villains will return to their old ways.
Source：https://www.cbr.com/spiderman-doctor-octopus-villains-no-longer-big-threats/
