Wolverine has long been an iconic member of the X-Men, and his most infamous nemesis was introduced shortly after his introduction. From there, it wasn't long before Victor Creed, aka Sabretooth, was putting as much effort as he could into destroying not just Wolverine, but everything the mutant hero loved.
Source：https://www.cbr.com/x-men-wolverine-sabretooth-virus-responsible-marvel/
