The expansive story of One Piece introduced a fantastic variety of supervillains and other antagonists. At first, Monkey D. Luffy thought that bad guys like Captain Kuro and Don Krieg in the East Blue saga were the worst of the worst, but then Luffy and his pals arrived on the Grand Line, where all the true villains resided. That included the likes of Sir Crocodile, Donquixote Doflamingo, and many more.
Source:https://www.cbr.com/one-piece-doflamingo-crocodile-worst-things/